topics / metabolic

Tagged metabolic.

3/10 · Animal only 5-Amino-1MQ A small-molecule NNMT inhibitor (not a peptide) studied for obesity and metabolic disease. The promising data are entirely in mice; there is no verifiable human trial and no approval.
1/10 · Unsupported AICAR AICAR (acadesine) is a small-molecule AMPK activator — not a peptide — famous for making sedentary mice run farther, but with no credible human evidence for endurance, fat loss, or longevity. It is an unapproved experimental drug, banned in sport at all times.
3/10 · Animal only Andarine (S4) A non-steroidal SARM with tissue-selective anabolic activity in rodents, but no completed human efficacy trials; clinical development was halted over vision side effects.
7/10 · Moderate Cardarine (GW-501516) Cardarine (GW-501516) is a synthetic PPARδ agonist, not a peptide or SARM, abandoned in development after rodent studies showed multi-organ cancer; it is banned in sport and has no approved human use.
7/10 · Moderate Clenbuterol Clenbuterol is a long-acting beta-2 adrenergic agonist (a bronchodilator and livestock 'repartitioning' agent) used off-label for fat loss — never FDA-approved for humans, banned in sport as an anabolic agent, and notable for serious cardiac and electrolyte toxicity. It is not a steroid and not a peptide.
1/10 · Unsupported DNP (2,4-Dinitrophenol) DNP is a synthetic mitochondrial uncoupler sold illegally as a 'fat burner' — never FDA-approved for human use, with no antidote and a long record of deaths. It is not a peptide and not a steroid.
3/10 · Animal only GW-0742 GW-0742 is a synthetic small-molecule PPARδ agonist and close sibling of cardarine (GW-501516) — not a peptide and not a SARM. It has no human efficacy data, a serious carcinogenicity concern inherited from its near-twin, and is banned in sport at all times.
10/10 · Established Insulin Insulin is a 51-amino-acid peptide hormone and one of medicine's most life-saving drugs for diabetes — but as a performance/anabolic agent in healthy people it has no good efficacy evidence and the highest acute lethality risk of common PEDs.
3/10 · Animal only LGD-3303 LGD-3303 is a nonsteroidal selective androgen receptor modulator (SARM), not a peptide. Its evidence is preclinical (rodent and equine) only — there are no human trials. It is an unapproved research chemical and is banned at all times in sport.
7/10 · Moderate Ligandrol (LGD-4033) Ligandrol (LGD-4033) is a nonsteroidal selective androgen receptor modulator (SARM), not a peptide. Its only real human data is a single 3-week Phase 1 trial; it is an unapproved drug, illegal to sell as a supplement, and banned in sport.
10/10 · Established Liothyronine (T3, Cytomel) Liothyronine is synthetic T3 thyroid hormone — an FDA-approved prescription drug (not a peptide), misused off-label as a fat-loss agent. Properly dosed and monitored it looks safe; the danger is dose-driven thyrotoxicosis from unsupervised overdose.
7/10 · Moderate Methylene Blue A synthetic redox dye with one strong, FDA-approved use (treating methemoglobinemia) and a long list of popular biohacking claims that human evidence does not support.
3/10 · Animal only MOTS-c MOTS-c is a mitochondrial peptide with strong rodent metabolic data but no completed, published human efficacy trial. It's unapproved and WADA-banned.
6/10 · Preliminary NMN NMN is a small-molecule NAD+ precursor that reliably raises blood NAD+ levels in humans, but its marketed anti-aging and metabolic benefits remain preliminary and surrogate-based.
7/10 · Moderate Ostarine (MK-2866) Ostarine is an investigational selective androgen receptor modulator (SARM) — not a peptide — with real but limited human evidence for lean-mass effects, no regulatory approval anywhere, and documented liver-injury and hormone-suppression signals.
8/10 · Good Oxandrolone (Anavar) Oxandrolone is an oral anabolic-androgenic steroid with genuine clinical trial support in catabolic illness (severe burns, HIV wasting, Turner syndrome), but its 'mild and safe' reputation is marketing, not evidence.
9/10 · Strong Oxymetholone (Anadrol) Oxymetholone is a potent oral anabolic-androgenic steroid (not a peptide) with genuine controlled-trial support in wasting illness, but it carries serious, well-documented liver, lipid, and hormonal risks.
3/10 · Animal only Testolone (RAD-140) An investigational, non-approved selective androgen receptor modulator (SARM) with no published human efficacy evidence for fitness use, a documented serious liver-injury case, and prohibited status in sport.
3/10 · Animal only S23 S23 is a synthetic selective androgen receptor modulator (SARM) — not a peptide — studied only in rodents as a male contraceptive candidate. There are no human trials, and it is an unapproved drug banned in sport.
3/10 · Animal only SLU-PP-332 SLU-PP-332 is a synthetic small-molecule pan-agonist of the estrogen-related receptors (ERRα/β/γ) studied as an 'exercise mimetic' — not a peptide, and animal-stage only with no human data.
10/10 · Established Somatropin (HGH) Recombinant human growth hormone — a protein hormone with strong evidence in true GH deficiency and specific medical conditions, but only small body-composition changes and no proven performance benefit in healthy adults. Non-medical distribution is a federal felony.
3/10 · Animal only Stenabolic (SR9009) SR9009 is a synthetic REV-ERB agonist (not a peptide, not a SARM) with intriguing mouse metabolic data but no credible human evidence, poor oral bioavailability, and documented off-target activity. Unapproved drug, banned in sport at all times.
10/10 · Established Tirzepatide (Mounjaro / Zepbound) A dual GIP/GLP-1 receptor agonist with strong RCT evidence for type 2 diabetes, weight loss, and sleep apnea; GI side effects are common.
1/10 · Unsupported Turkesterone An ecdysteroid (plant/insect steroid) marketed as a 'natural anabolic,' but with essentially no direct human evidence for muscle or strength benefits — the supporting science is mostly about the related compound 20-hydroxyecdysone and is itself weak and mixed.
3/10 · Animal only YK-11 YK-11 is a synthetic steroidal SARM marketed for muscle growth, but its claimed human benefits rest entirely on cell-culture data — there are no human trials, and it is an unapproved drug banned in sport.